A new benzophenone isolated from fibrous roots of Anemarrhena asphodeloides.
10.19540/j.cnki.cjcmm.20190118.004
- Author:
Zhen-Dong LIAO
1
;
Feng-Qing XU
2
;
De-Ling WU
3
;
Wei ZHANG
3
;
Qi HUANG
2
Author Information
1. School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China.
2. School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China Anhui Key Laboratory of Modern Chinese Materia Medica Hefei 230012, China.
3. School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China Anhui Key Laboratory of Modern Chinese Materia Medica Hefei 230012, China Province Key Laboratory of Traditional Chinese Medicine Decoction Pieces of New Manufacturing Technology Hefei 230012, China.
- Publication Type:Journal Article
- Keywords:
SH-SY5Y cells;
chemical constituent;
fibrous roots of Anemarrhena asphodeloides
- MeSH:
Anemarrhena;
chemistry;
Benzophenones;
isolation & purification;
pharmacology;
Cell Line;
Chromatography, High Pressure Liquid;
Humans;
Neuroprotective Agents;
isolation & purification;
pharmacology;
Phytochemicals;
isolation & purification;
pharmacology;
Plant Roots;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(7):1392-1396
- CountryChina
- Language:Chinese
-
Abstract:
Five compounds were isolated from the fibrous roots of Anemarrhena asphodeloides by silica gel, Sephadex LH-20 and semi-HPLC column chromatography. On the basis of physic-chemical properties and spectroscopic data analysis, these compounds were identified as methyl 2-[2,4-dihydroxy-3-(4-hydroxybenzoyl)-6-methoxyphenyl]acetate(1), 4-[formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoate(2), perlolyrine(3),syringaresinol-4'-O-β-D-glucoside(4) and 4',6-dihydroxy-4-methoxybenzophenone-2-O-(2″),3-C-(1″)-1″-desoxy-α-L-fructofuranoside(5). Among them, 1 was a new benzophenone. Compounds 2-5 were isolated from this plant for the first time. Compound 1 was tested for neuroprotective effects against H_2O_2-induced damage in SH-SY5 Y cells.
