Increased Postprandial Colonic Motility and Autonomic Nervous System Activity in Patients With Irritable Bowel Syndrome: A Prospective Study
- Author:
Yukari TANAKA
1
;
Motoyori KANAZAWA
;
Olafur S PALSSON
;
Miranda A VAN TILBURG
;
Lisa M GANGAROSA
;
Shin FUKUDO
;
Douglas A DROSSMAN
;
William E WHITEHEAD
Author Information
- Publication Type:Original Article
- Keywords: Autonomic nervous system; Gastrointestinal Motility; Irritable bowel syndrome; Postprandial period
- MeSH: Autonomic Nervous System; Colon; Colon, Descending; Eating; Gastrointestinal Motility; Heart Rate; Humans; Irritable Bowel Syndrome; Manometry; Meals; Postprandial Period; Prevalence; Prospective Studies
- From:Journal of Neurogastroenterology and Motility 2018;24(1):87-95
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The prevalence and severity of irritable bowel syndrome (IBS) declines with age, but the cause of this is unknown. This study tested 2 hypotheses: (1) autonomic nervous system responses to eating and bowel distention, measured by heart rate variability (HRV), differs by age in IBS patients and (2) HRV is correlated with colonic motility and IBS symptoms. METHODS: One hundred and fifty-six Rome III positive IBS patients and 31 healthy controls underwent colonic manometry with bag distention in the descending colon, followed by ingestion of an 810-kcal meal. HRV, evaluated by low frequency (%LF; 0.04–0.15 Hz) component, high frequency (%HF; 0.15–0.40 Hz) component, and the LF/HF ratio, was measured during colonic distention and after the meal. Motility index and subjective symptom scores were simultaneously quantified. RESULTS: Both colonic distention and eating decreased %HF and increased the LF/HF ratio, and both indices of autonomic nervous system correlated with age. In IBS patients, %HF negatively correlated with the postprandial motility index after adjusting for age. The %HF and LF/HF ratios also correlated with psychological symptoms but not bowel symptoms in IBS patients. CONCLUSION: Decreased vagal activity is associated with increase in age and greater postprandial colonic motility in patients with IBS, which may contribute to postprandial symptoms.
