White Matter Microstructural Similarity and Diversity of Functional Constipation and Constipation-predominant Irritable Bowel Syndrome
- Author:
Jiaofen NAN
1
;
Liangliang ZHANG
;
Qiqiang CHEN
;
Nannan ZONG
;
Peiyong ZHANG
;
Xing JI
;
Shaohui MA
;
Yuchen ZHANG
;
Wei HUANG
;
Zhongzhou DU
;
Yongquan XIA
;
Ming ZHANG
Author Information
- Publication Type:Original Article
- Keywords: Brain; Diffusion tensor imaging; Irritable bowel syndrome
- MeSH: Abdominal Pain; Anisotropy; Brain; Constipation; Corpus Callosum; Diffusion; Diffusion Tensor Imaging; External Capsule; Female; Humans; Irritable Bowel Syndrome; White Matter
- From:Journal of Neurogastroenterology and Motility 2018;24(1):107-118
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The Rome III criteria separated chronic constipation into functional constipation (FC) and constipation-predominant irritable bowel syndrome (IBS-C), but some researchers questioned the partitioning and treated both as distinct parts of a continuum. The study aims to explore the similarity and diversity of brain white matter between FC and IBS-C. METHODS: The voxel-wise analysis of the diffusion parameters was used to quantify the white matter changes of female brains in 18 FC patients and 20 IBS-C patients compared with a comparison group with 19 healthy controls by tract-based spatial statistics. The correlations between diffusive parameters and clinical symptoms were evaluated using a Pearson’s correlation. RESULTS: In comparison to healthy controls, FC patients showed a decrease of fractional anisotropy (FA) and an increase of radial diffusivity (RD) in multiple major fibers encompassing the corpus callosum (CC, P = 0.001 at peak), external capsule (P = 0.002 at peak), corona radiata (CR, P = 0.001 at peak), and superior longitudinal fasciculus (SLF, P = 0.002 at peak). In contrast, IBS-C patients showed FA and RD aberrations in the CC (P = 0.048 at peak). Moreover, the direct comparison between FC and IBS-C showed only RD differences in the CR and SLF. In addition, FA and RD in the CC were significantly associated with abdominal pain for all patients, whereas FA in CR (P = 0.016) and SLF (P = 0.040) were significantly associated with the length of time per attempt and incomplete evacuation separately for FC patients. CONCLUSION: These results may improve our understanding of the pathophysiological mechanisms underlying different types of constipation.
