A Case of Vancomycin-Induced Thrombocytopenia.
10.5045/kjh.2009.44.4.294
- Author:
Jae Hyeon LEE
1
;
Dal Sik KIM
;
Hye Soo LEE
;
Sam Im CHOI
;
Yong Gon CHO
Author Information
1. Department of Laboratory Medicine, Chonbuk National University Medical School, Jeonju, Korea. choyg@jbnu.ac.kr
- Publication Type:Case Report
- Keywords:
Thrombocytopenia;
Vancomycin;
Drug-induced
- MeSH:
Aged;
Antibodies;
Humans;
Male;
Platelet Transfusion;
Thrombocytopenia;
Vancomycin
- From:Korean Journal of Hematology
2009;44(4):294-297
- CountryRepublic of Korea
- Language:English
-
Abstract:
Immune thrombocytopenia is a rare complication associated with vancomycin. A 76-year-old male patient who was treated with vancomycin experienced severe thrombocytopenia and refractoriness as a result of platelet transfusion. Vancomycin-dependent antibodies in his thrombocytopenic serum were detected by flow cytometric analysis. The mechanism of thrombocytopenia is probably related to immunological destruction, as strongly suggested by its association with a specific drug-dependent anti-platelet antibody.
