Damage-Associated Molecular Patterns in Inflammatory Diseases.
- Author:
Jong Seong ROH
1
;
Dong Hyun SOHN
Author Information
- Publication Type:Review
- Keywords: Damage-associated molecular patterns; Inflammation; Pattern recognition receptors; Inflammatory diseases
- MeSH: Alzheimer Disease; Arthritis, Rheumatoid; Atherosclerosis; Biomarkers; Heat-Shock Proteins; Immune System; Inflammation; Lupus Erythematosus, Systemic; Osteoarthritis; Parkinson Disease; Receptors, Pattern Recognition; S100 Proteins
- From:Immune Network 2018;18(4):e27-
- CountryRepublic of Korea
- Language:English
- Abstract: Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses. Recent studies have suggested that various DAMPs, such as high-mobility group box 1 (HMGB1), S100 proteins, and heat shock proteins (HSPs), are increased and considered to have a pathogenic role in inflammatory diseases. Here, we review current research on the role of DAMPs in inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, atherosclerosis, Alzheimer's disease, Parkinson's disease, and cancer. We also discuss the possibility of DAMPs as biomarkers and therapeutic targets for these diseases.
