Changes of irisin in patients with end-stage renal disease before and after hemodialysis
10.3760/cma.j.issn.1001-7097.2017.12.003
- VernacularTitle:终末期肾脏病患者血液透析前后血浆鸢尾素水平的变化
- Author:
Chengying YUAN
1
;
Xiaoshuang ZHOU
;
Rongshan LI
Author Information
1. 山西医科大学附属人民医院山西省人民医院肾内科
- Keywords:
Renal dialysis;
Diabetes;
Energy metabolism;
Irisin
- From:
Chinese Journal of Nephrology
2017;33(12):895-899
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of irisin in patients before and after hemodialysis (HD),as well as the differentiation of irisin change in patients with diabetes mellitus and protein energy waste.Methods Clinical parameters of patients on maintenance hemodialysis (MHD)in Shanxi People's Hospital from September 2016 to November 2016 were collected.A total of 33 cases were enrolled——14 cases of diabetic MHD group and 19 cases of non-diabetic MHD group as divided according to etiology.Based on the presence of protein energy waste,patients were also grouped into 17 cases with and 16 cases without protein waste.Before and after HD,the non parametric test was used to compare the changes of irisin in each group.Results After HD,the irisin value of 33patients with ERSD decreased,with the difference being statistically significant [0.666(0.218,1.365) ng/L vs 0.977(0.202,1.820) ng/L,P=0.01].The difference was not statistically significant in the diabetes MHD group;statistically significant in the non diabetes group [0.666(0.178,1.351) ng/L vs 0.913(0.100,1.497) ng/L,P ＜ 0.05];and not statistically significant in the protein energy group.The irisin of diabetic MHD group and non-diabetic MHD group were compared after HD:the difference was not statistically significant.Conclusions After HD,plasma irisin levels were reduced in patients with end-stage renal disease.Diabetes and protein wasting effects are not important for irisin at HD.
