Effects of three preparation technologies on the oral bioavailability of berberine α-hydroxy β-decanoylethyl sulfonate

VernacularTitle:3种制剂技术对黄癸素口服生物利用度的影响
Author: Hui LI ¹ ; Man LIU ; Hong-Bo HUANG ; Jin-Song DING
Author Information

1. 中南大学湘雅药学院
Keywords: berberine α-hydroxy β-decanoylethyl sulfonate (HB); solid dispersions; HP-β-CD inclusion complexes; nanosuspension freeze-dried powders; oral bioavailability; HPLC-MS/MS
From: Chinese Traditional Patent Medicine 2018;40(2):309-313
CountryChina
Language:Chinese
Abstract: AIM To compare the effects of three preparation technologies on the oral bioavailability of HB (berberine α-hydroxy β-decanoylethyl sulfonate,houttuyn berberine).METHODS Solid dispersions,HP-β-CD inclusion complexes and nanosuspension freeze-dried powders were prepared.The suspensions of crude drug and these three preparations were intragastrically administered to SD rats,respectively.HPLC-MS/MS was adopted in the content determination of HB in plasma.then pharmacokinetics parameters were calculated.RESULTS Compared with the crude drug,three preparation technologies could significantly increase the Cmax value of this component (P ＜ 0.05),especially for HP-β-CD inclusion complexes (P ＜ 0.01).And HP-β-CD inclusion complexes demonstrated much higher AUC0-6h than the crude drug and the other two preparation technologies (P ＜ 0.05).CONCLUSION HP-β-CD inclusion complexes can effectively increase the oral bioavailability of HB.