Effect of Genetic Polymorphism in CYP2C9 and VKORC1 on Warfarin Used in Pregnant Patients with Mechanical Valve Replacement
- VernacularTitle:CYP2C9和VKORC1基因多态性对机械瓣膜置换妊娠患者华法林应用的影响及分析
- Author:
Jinhua ZHANG
1
;
Jianmei WU
;
Hua CAO
Author Information
1. 福建医科大学附属协和医院药学部 福州350001
- Keywords:
Warfarin;
Pregnant;
Genetic polymorphism;
CYP2C9;
VKORC1;
Heart valve replacement
- From:
China Pharmacist
2018;21(10):1790-1793
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effects of genetic factors and non-genetic factors on warfarin dosage in pregnant women after heart valve replacement. Methods: Totally 68 pregnant women were treated with warfarin throughout pregnancy. PCR-chip method was used to detect the polymorphism of CYP2C9 and VKORC1 gene,and the clinical data were collected. The effects of genetic factors and non-genetic factors on stable dosage of warfarin were statistically analyzed. Results: CYP2C9, VKORCl genotypes and weight had sig-nificant effects on warfarin dosage. The three variables could explain 44. 6% of warfarin individual differences. Conclusion: Genetic factors have significant effect on warfarin dosage in pregnant patients, so the detection of genetic polymorphism of CYP2C9 and VKORCl can be applied to individualize warfarin dosage in pregnant patients with heart valve replacement.
