A Case Discussion of Individualized Administration of Warfarin by Maximum a Posteriori Bayesian Estima-tion Method
10.3969/j.issn.1008-049X.2018.03.015
- VernacularTitle:最大后验贝叶斯估算法制定华法林个体化给药案例探讨
- Author:
Jinhua ZHANG
1
;
Fang FU
;
Jianmei WU
;
Qiang CHEN
;
Hua CAO
Author Information
1. 福建医科大学附属协和医院药学部 福州350001
- Keywords:
Maximum a posteriori Bayesian;
Warfarin;
Individualized administration;
Clinical pharmacist;
Pharmaceutical care
- From:
China Pharmacist
2018;21(3):435-437
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role played by clinical pharmacists in the formulation and pharmaceutical care of individual-ized administration of warfarin. Methods:Clinical pharmacists adopted maximum a posteriori Bayesian method to formulate the dosage regimen of patients treated with warfarin and monitored the implementation process. The increase of INR was timely identified on ac-count of drug interactions to avoid bleeding events,as well as the decrease of INR caused by patients' medication mistakes to avoid re-currence of thrombosis. Results:The maximum a posterior Bayesian estimation method could be used to estimate and guide clinical medication,which showed great reference value for individualized drug regimen. Conclusion:Clinical pharmacists should formulate in-dividualized administration plan according to genetic testing results and choose optimal treatment for patients. Moreover,the implemen-tation of dosage regimen should be monitored during the whole progress,so as to timely find INR abnormal fluctuations due to disease interactions,drug interactions,poor treatment compliance and so on,and consequently improve anticoagulant effect and reduce adverse reactions such as bleeding and thrombosis etc.
