Research progress of muscle atrophy animal models
10.3969/j.issn.1001-1978.2018.04.002
- VernacularTitle:秀丽隐杆线虫模型在肌肉萎缩症研究中的应用
- Author:
Shu-Mei MA
1
;
Li LIU
Author Information
1. 上海医药工业研究院药理评价研究中心
- Keywords:
model organism;
dystrophin;
Caenorhabditis ele-gans;
mouse models for duchenne muscular dystrophy;
Canine models for duchenne muscular dystrophy
- From:
Chinese Pharmacological Bulletin
2018;34(4):449-452
- CountryChina
- Language:Chinese
-
Abstract:
An effective therapeutic method for muscular dystro-phy is unavailable now;however,the research and development of anti-muscular dystrophy drugs need appropriate animal mod-els. Researchers focus on Caenorhabditis elegans because of the andvantages such as the transparent body, short life cycle, and high homology with human genes. The Caenorhabditis elegans mutant strains show musucular dystrophy phenotype similar to human diseases. In this paper,the application of Caenorhabditis elegans models in muscular dystrophy research has been re-viewed.
