Association study of interaction of tryptophan hydroxylase 2 with serotonin 1A receptor gene polymorphism on major depressive disorder
10.3760/cma.j.issn.1674-6554.2018.02.013
- VernacularTitle:TPH2和5-HT1A基因多态性交互作用与抑郁症的关联研究
- Author:
Xueyan ZHAO
1
;
Jiarun YANG
;
Chunyang ZHANG
;
Ning YAN
;
Xusheng SONG
;
Jian ZHANG
;
Jingsong MA
;
Lin WANG
;
Xiuxian YANG
;
Yanjie YANG
Author Information
1. 哈尔滨医科大学公共卫生学院医学心理学教研室
- Keywords:
Major depressive disorder;
Tryptophan hydroxylase 2;
Serotonin 1A receptor;
Gene-gene interaction
- From:Chinese Journal of Behavioral Medicine and Brain Science
2018;27(2):165-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the interaction between tryptophan hydroxylase 2(TPH2) gene polymorphisms (rs4570625,rs11178997) and serotonin 1A receptor (5-HT1A) gene polymorpbisms (rs878567,rs1364043,rs6265) and the association with major depressive disorder (MDD) in a Chinese Han population.Methods The DNA isolated from peripheral blood samples of 288 MDD patients 288 healthy subjects was detected by single base primer extension assay (Snapshot).The generalized multifactor dimensionality reduction (GMDR) method was used to analyze the gene-gene interaction.Results Significant differences were found in the genotype (patients (TT:27,TA:152,AA:109),controls (TT:82,TA:105,AA:101),P＜0.01) and allele(patients (T:206,A:370),controls (T:269,A:307),P＜0.01) frequencies of rs1 1178997 within TPH2 between MDD patients and controls.Statistically,a greater risk of developing MDD was found in individuals with an rs1 1178997 A-allele(OR=1.574,95％CI=1.243-1.993).The interaction between TPH2 (rs4570625,rs1 1178997) and 5-HT1A (rs878567,rs1364043,rs6265) was considered as the best multi-locus model,and this showed a testing accuracy of 57.67％ and a CV consistency of 10/10.And this interaction had a significant effect on the risk of MDD (P=0.0107).Conclusion There may be an association between the interaction of TPH2 and 5-HT1A polymorphisms and MDD.
