Profile of serum lipoprotein in patients with subclinical hypothyroidism.
- Author:
Wou Weon LEE
1
;
Chung Hwan KIM
;
Yoo Seock CHEONG
;
Sun Mi YOO
;
Il Hwan PARK
;
Seouk Gun PARK
Author Information
1. Department of Family Medicine, Nuclear Medicine, College of Medicine, Dankook University, Korea.
- Publication Type:Original Article
- Keywords:
subclinical hypothyroidism;
serum lipid profile(total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein)
- MeSH:
Atherosclerosis;
Body Mass Index;
Cholesterol;
Cholesterol, LDL;
Dissent and Disputes;
Humans;
Hyperlipidemias;
Hypothyroidism*;
Lipoproteins*;
Triglycerides
- From:Journal of the Korean Academy of Family Medicine
2000;21(3):376-381
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Overt hypothyroidism is a well-known cause of secondary hyperlipidemia and atherosclerosis. However, there have been some dissenting report of abnormalities and in serum lipid concentration in patients with subclinical hypothyroidism. We have attempted to analyze serum lipid concentrations to investigate whether they are increased in patients with subclinical hypothyroidism and to see if there is a correlation between serum LDL-C and TSH concentrations. METHODS: Serum lipid profiles(total cholesterol, triglycerides, LDL-C, HDL-C) of patients with subclinical hypothyroidism (M/F=7/119) compared with age, sex and body mass index matched control subjects(M/F=14/239) from Jan. 1 . 1996. to Dec. 30. 1997. RESULTS: There were no significant differences of serum total cholesterol, LDL cholesterol, TG, and HDL concentrations in 126 patients with subclinical hypothyroidism and 253 control subjects(178.47+/-35.76mg/dL vs. 173.05+/-35.93mg/dL ; 113.33+/-52.89mg/dL vs 117.64+/-68.70mg/dL ; 112.89+/-33.26mg.dL vs 109.65+/-29.02mg/dL ; 48.60+/-11.34mg/dL vs 46.51+/-11.73mg/dL). There was no correlation between LDL cholesterol and TSH concentrations in subclinical hypothyroidism(r=0.29, p<0.05). CONCLUSION: Serum lipid concentration (total cholesterol, LDL cholesterol, and TG, HDL) was not increased in patients with subclinical hypothyroidism. There was no correltion between serum LDL and TSH levels in patients with subclinical hypothyroidism.