Effects of ginsenoside Rh1 on expression of inflammatory factors in mouse asthma model
10.3969/j.issn.1000-4718.2018.01.028
- VernacularTitle:人参皂苷Rh1对哮喘模型小鼠炎症因子表达的抑制作用
- Author:
Chun-Jing ZHANG
1
;
Shu-Yan LI
;
Rong-Jie ZHAO
;
Zheng-Lin ZHAO
Author Information
1. 齐齐哈尔医学院 生物化学教研室
- Keywords:
Bronchial asthma;
Ginsenoside Rh1;
Inflammatory factors;
Lung tissue
- From:Chinese Journal of Pathophysiology
2018;34(1):163-167
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the effects of ginsenoside Rh 1 on the levels of inflammatory factors in serum and bronchoalveolar lavage fluid(BALF),and the pathological changes of the lung tissues in an experimentally induced mouse asthma model.METHODS:Male BALB/c mice(n=40)were divided into 4 groups:normal control group,asthma mo-del group,and low-dose(40 mg· kg-1 · d-1 )and high-dose(80 mg· kg-1 · d-1 )ginsenoside Rh1 groups.The bron-chial asthma mouse model was established by the method of ovalbumin induction and excitation ,and during the excitation period,the mice were daily treated with ginsenoside Rh 1 for 2 weeks.At 24 h after the final dose of ginsenoside Rh 1,the mice were sacrificed.The number of eosinophils(EOS)and the concentrations of interleukin(IL)-4,IL-5 and interferon(IFN)-γin BALF were determined.The levels of IgG and IgE in serum were measured ,and the expression of transforming growth factor(TGF)-β1 and the pathological changes in lung tissues were evaluated.RESULTS:Ginsenoside Rh1 inhibi-ted the increases in the number of EOS and the concentrations of IL-4,IL-5,IFN-γand IgE,reversed the increased ex-pression of TGF-β1,and improved the pathological changes of the lung tissues in asthmatic mice.CONCLUSION:Gin-senoside Rh1 improves the immuno-inflammatory profile and pathological changes in the experimentally induced mouse asth -ma model,implying its potential therapeutic effect on asthma.
