Changes of BDNF in patients with depression at perimenopausal period after treatment with venlafaxine

VernacularTitle:围绝经期抑郁症患者文拉法辛治疗前后脑源性神经营养因子的变化
Author: Hezeng YANG ¹ ; Fei SHAN ; Minzhi LI
Author Information

1. 深圳市康宁医院、深圳市心理健康实验室广东深圳518020
Keywords: depression; perimenopause; brain-derived neurotrophic factor; antidepressive drugs
From: The Journal of Practical Medicine 2018;34(3):457-459
CountryChina
Language:Chinese
Abstract: Objective To explore the changes of depressive symptoms and serum level of brain derived neurotrophic factor(BDNF)before and after venlafaxine treatment in female patients with depression. Methods 40 perimenopausal women patients with depression received treatment with venlafaxine for 4 weeks. Before and after treatment,the patients were assessed by the Hamilton Depression Scale(table 24 item version)and serum levels of BDNF were measured. The results were compared with those from 40 healthy menopausal women. Results In the treatment group,the depressive symptoms were improved(P < 0.05);and the BDNF level was elevated(P < 0.05). The serum BDNF levels were higher in the effective group than in the non-effective group (P<0.05);the BDNF levels were increased(P<0.05)before and after treatment.Conclusions Treatment with venlafaxine for depression in perimenopausal women,BDNF levels are increased and depression symptoms are mproved significantly.The effect is associated with the level of BDNF.