Berberine Effect of Anti-microbiota-Possibility and Clinical Significance on Gut Microbiota and Metabolism: A Review
- VernacularTitle:小檗碱抑菌作用的研究:调控肠道菌代谢的可能性及其意义
- Author:
Huiyu LI
1
;
Zhiyi YUAN
;
Yugang WANG
;
Fan LEI
;
Dongming XING
;
Weidong XIE
;
Jun LI
;
Lijun DU
Author Information
- Keywords: Berberine; gut; microbiota; gene transcription
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2017;19(4):596-601
- CountryChina
- Language:Chinese
- Abstract: Berberine (BBR) is known as a classic drug for intestinal infection treatment.BBR inhibits intestinal bacteria,which is the core of its role in the treatment of intestinal infection.With the survival of local intestinal bacteria and its related metabolites on the physiological and pathological functions of the body continue to recognize the impact of it,more and more literatures have presented the effect of BBR through the impact of intestinal bacteria on the body glycol-lipid metabolism,even brain function.This allows us to re-understand the pathophysiology of BBR in inhibiting gut microbiome.In this paper,the antibacterial activity of BBR was reviewed and analyzed.The possible molecular target of BBR was analyzed according to the characteristics of prokaryotes gene expression,which was helpful to the in-depth study of BBR on intestinal bacteria.Thus,a more comprehensive understanding of the pharmacological effects of BBR is given.
