Association Analysis between Genetic Polymorphisms of CYP4A11, Apolipoprotein B and E Genes and Essential Hypertension Susceptibility
10.3969/j.issn.1003-4706.2018.05.015
- VernacularTitle:CYP4A11和载脂蛋白B、E基因多态性与原发性高血压患病风险的相关性
- Author:
Yi-Qing LU
1
Author Information
1. 西安市第一医院心血管科
- Keywords:
Essential hypertension;
CYP4A11;
ApoB;
ApoE;
Ggene polymorphisms
- From:
Journal of Kunming Medical University
2018;39(5):70-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between single nucleotide polymorphisms (SNPs) in CYP4A11 and ApoB、 ApoE genesandthe risk of essential hypertension. Methods By means of correlation analysis, this case-controlled study included a total of 350 essential hypertension patients admitted in the first Hospital of Xi'an from June 2012 to December 2016, and another 350 cases with matched ages and sexes enrolled for routine check-ups as the healthy control group. The genotypes of CYP4A11 and ApoB、 ApoE genes were determined by MassARRAY method. SPSS 21.0 software was used to determine the correlation between SNPs and the risk of primary hypertension.Results Comparing the allele frequencies of SNPs, we found rs1126742 (OR=1. 45, 95 % CI, 1.09-1.92,P=0.008)、 rs3890011 (OR=1.98, 95 % CI, 1.06-1.85, P=0.001) and rs9332978 (OR=1.54, 95%CI, 1.27-1.91,P=0.004) on CYP4A11 were significantly associated with an increased risk of essential hypertension; XbaⅠpolymorphism in ApoB gene was associated with essential hypertension risks (OR=1.55,95%CI, 1.15-2.55,P=0.001);ε4 in ApoE gene was also found associated with essential hypertension risks (OR=1.49, 95 % CI, 1.09-2.35, P=0.012), while ε2 andε3 not associated.Comparing the genotype frequencies of SNPs,we found the GG genotype of rs9332978, TC and CC genotype of rs1126742, CG and GG genotypes of rs3890011 were associated with increased risks of essential hypertension (P＜0.05) .The X -X- genotype of XbaⅠin ApoB gene were associated with increased risks of essential hypertension (OR=2.45, 95%CI, 1.25-3.25, P=0.035) . The E2/E4、E3/E4、E4/E4 genotype of ApoE were associated with increased risks of essential hypertension (P＜0.05).In the genetic model analysis, we found that the minor allele "A" of rs9332978 was associated with an increased risk of essential hypertension under dominant model (P＜0.05) . The minor allele "T" of rs1126742 was associated with increased risks essential hypertension under dominant and recessive models (P＜0.05) . Conclusion Gene polymorphisms of CYP4A11、ApoB and ApoE play an important role in the occurrence and development of essential hypertension.
