Diabetes, hypoglycemic drugs and pancreatic cancer
10.3760/cma.j.issn.1673-422X.2018.03.013
- VernacularTitle:糖尿病及降糖药物与胰腺癌
- Author:
Biyu LIANG
1
;
Weiming HE
;
Xiaoyi HE
;
Yuanlin DING
;
Haibing YU
Author Information
1. 广东医科大学流行病与卫生统计学教研室
- Keywords:
Pancreatic neoplasms;
Diabetes mellitus;
Hypoglycins;
Molecular mechanisms of pharmacological action
- From:
Journal of International Oncology
2018;45(3):183-186
- CountryChina
- Language:Chinese
-
Abstract:
About 80％ of the patients with pancreatic cancer have glucose metabolism alterations,which suggests an association between diabetes and the occurrence and development of pancreatic cancer.Studies have shown that diabetes and hypoglycemic agents are closely related to the occurrence risk,clinical manifestation and prognosis of pancreatic cancer.Recent findings demonstrate that insulin resistance,hyperinsulinemia,the expression level of insulin-like growth factor related protein and inflammatory reaction are the possible mechanisms of the interaction between diabetes and pancreatic cancer.However,the definite mechanism still remains unclear,and further researches are still needed.
