Anticancer mechanism and application of curcumin analog EF24

VernacularTitle:姜黄素类似物EF24的抗肿瘤机制与应用
Author: Xiaofei LING ^{1
,

2} ; Ke XU ; Hua SHAO ; Cuijuan WANG
Author Information

1. 250062 济南大学山东省医学科学院医学与生命科学学院
2. 山东省医学科学院山东省职业卫生与职业病防治研究院理化实验室
Keywords: Antineoplastic agents; Curcumin; EF24
From: Journal of International Oncology 2018;45(3):172-175
CountryChina
Language:Chinese
Abstract: Curcumin is a polyphenol pigment product from the rhizome of curcumin longa.It is associated with numerous therapeutic benefits,including antioxidant,anti-inflammatory and anticancer activities.Research shows that EF24 is a curcumin analog that can induce tumor cell apoptosis,arrest cell cycle,inhibit cell invasion and metastasis and has synergistic effect of combined antitumor agents.EF24 has improved anticancer activity and bioavailability against various cancer cell lines over curcumin without increased toxicity.EF24 would have great potential to be used as a useful therapeutic agent for the treatment of various types of cancer.