Research progress on glycolipid metabolism regulating of FGF19 and FGF21 in adipose tissue
10.3760/cma.j.issn.1673-4181.2017.06.016
- VernacularTitle:FGF19及FGF21在脂肪组织中调节糖脂代谢作用的研究进展
- Author:
Ruyi XU
1
;
Wei JIANG
Author Information
1. 150001,哈尔滨医科大学附属第一医院内分泌科
- Keywords:
Adipose tissue;
Fibroblast growth factor 19;
Fibroblast growth factor 21;
Adipokine;
Glucose and lipid metabolism
- From:International Journal of Biomedical Engineering
2017;40(6):482-485
- CountryChina
- Language:Chinese
-
Abstract:
Adipose tissue is not only an energy storage organ, but also an endocrine organ involved in metabolic processes. It has the function of secreting various adipokines, such as leptin, adiponectin, etc. Adipose tissue and adipokines are involved in the regulation of glucose and lipid metabolism, which show great value in the study of metabolic diseases such as diabetes and obesity. As a fibroblast growth factor (FGFs), the family of protein hormone-like factors 19 (FGF19) and FGF21 have roles in decreasing body weight, increasing insulin sensitivity, improving blood lipid spectrum, etc. FGF19 and FGF21 are promising target drugs for the treatment of metabolic diseases. The recent research progress on the glycolipid metabolism regulating of FGF19 and FGF21 in adipose tissue were summarized and the application prospects were reviewed.
