Neuroprotective effect of uric acid in cerebral ischemia-reperfusion injury
10.3760/cma.j.issn.1673-4165.2018.09.010
- VernacularTitle:尿酸在脑缺血再灌注中的神经保护作用
- Author:
Lingling SHEN
1
,
2
;
Dan LU
;
Keshen LI
;
Anding XU
Author Information
1. 510630 广州,暨南大学附属第一医院神经内科与脑血管病中心
2. 510630 广州,暨南大学临床神经科学研究所
- Keywords:
Brain Ischemia;
Reperfusion Injury;
Stroke;
Uric Acid;
Oxidative Stress;
Antioxidants;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2018;26(9):701-707
- CountryChina
- Language:Chinese
-
Abstract:
Uric acid is an end product of purine metabolism. A large number of clinical studies have shown that high-level serum uric acid is a good predictor of outcome in patients with acute ischemic stroke. Oxidative stress is the main mechanism of cerebral ischemia-reperfusion injury. As a potent antioxidant, uric acid is considered to have a potential neuroprotective effect in the vascular recanalization treatment, but its specific mechanism remains unclear. This article reviews the neuroprotective mechanism of uric acid in cerebral ischemia-reperfusion injury in order to provide ideas for future research and clinical practice.
