Association of interleukin-10 gene polymorphism with bronchial asthma in Chinese subjects in Beijing area

VernacularTitle:白细胞介素10基因多态性与北京地区哮喘病患者的相关性研究
Author: Xu ZHANG ¹ ; Yuhong WANG ; Yuan ZHANG ; Luo ZHANG
Author Information

1. 首都医科大学附属北京同仁医院过敏科
Keywords: Asthma; Interleukin-10; Polymorphism; Single Nucleotide
From: Chinese Archives of Otolaryngology-Head and Neck Surgery 2018;25(1):35-37
CountryChina
Language:Chinese
Abstract: OBJECTIVE The objective of this study was to investigate the association between interleukin 10 (IL-10) gene polymorphism and asthma. METHODS We tried to enroll data from 205 asthma patients and 210 controls to investigate the association between IL-10 polymorphisms and asthma in the Han Chinese population. The three common single nucleotide polymorphisms (SNPs), including rs1800896, rs1800871, rs1800872 on the promoter area of IL-10 were genotyped using the sequenom mass array technology platform. RESULTS Our results showed that rs1800872 were significantly associated with asthma. In asthma groups, we found that there was significant high concentration of total serum IgE in genotype AA comparing with genotype CC. CONCLUSION In conclusion, our data showed that rs1800872 was significantly associated with asthma.