Current status of neuroprotection in cerebrovascular disease
- VernacularTitle:脑血管病神经保护治疗的现状、趋势及存在问题
- Author:
Xinfeng LIU
;
- Publication Type:Journal Article
- Keywords:
Neuroprotection;
Cerebral ischemia;
Blood brain barrier
- From:
Journal of Medical Postgraduates
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The role of neuroprotection in the treatment of acute cerebrovascular disease is reviewed. Various neuroprotective strategies include ion channel modulators,anti excitotoxic agents,free radical scavengers,neurrotrophic factors,hypothermia,gene therapy and stem cells. The various agents aim to prevent the progression of ischemic cascade therefore reducing brain injury through more than one point in the ischemic cascade. Clinical effectiveness of most of the strategies has not been proven in clinical trials. Some of which had to be abandoned due to adverse effects outweighing the beneficial effects. At least six neuroprotective agents based on various mechanisms are in phase Ⅲ of clinical trials. The most promising appear to be free radical scavengers and anti excitotoxic agents.
