Identification of andrographolide hydroxypropyl-?-cyciodextrin inclusion compound and study on its thermodynamic stability
- VernacularTitle:穿心莲内酯-羟丙基-?-环糊精包合物的鉴定和热力学稳定性研究
- Author:
Ke REN
;
Zhi-Rong ZHANG
;
Jing-Hong JU
;
Yang LIU
;
Tao GONG
;
- Publication Type:Journal Article
- Keywords:
andrographolide;
inclusion compound;
differential scanning calorimetry(DSC);
infrared spectrometry(IR);
X-ray diffraction(XRD);
phase solubility
- From:
Chinese Traditional and Herbal Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare and identify the andrographolide-hydroxypropyl-?-cyclodextrin(an- drographolide-HP-?-CD)inclusion compound.The tool ratio between andrographolide and HP-?-CD and the thermodynamic constants in inclusion were studied simultaneously.Methods The andrographolide- HP-?-CD inclusion compound was prepared with lyophilization technique.Meanwhile,the inclusion com- pound was identified by differential scanning calorimetry(DSC)methods,infrared spectrometry(IR),and X-ray diffraction(XRD),respectively.The tool ratio between host and guest moleculars and the thermo- dynamic constants during the inclusion process were also researched by phase solubility method.Results An 1:1 molar ratio inclusion complex of andrographolide with HP-?-CD could be formed at 25,35,and 45 C.The phase diagram was A_L type and the procedure of inclusion was a heat release process.Conclusion The solubility of andrographolide-HP-?-CD inclusion compound can be increased obviously by the above- mentioned preparing techniques.
