An experimental study of mild hypothermia via lateral ventricle perfusion of cool Ringer's solution in rabbits after traumatic brain injury
- VernacularTitle:经侧脑室对创伤性脑损伤进行亚低温治疗的疗效观察
- Author:
Guang-Wei WANG
;
Yun FENG
;
- Publication Type:Journal Article
- Keywords:
Lateral ventricle;
Hypothermia;
Brain injuries
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To set up a new method of mild hypothermia via lateral ventricle in rabbits following traumatic brain injury (TBI). Methods Twenty-one New Zealand rabbits were used for this study. TBI was pro- duced with all the rabbits in anesthesia by using free-falling impact model. Animals were randomly divided into three groups: a TBI group, a mild hypothermia group (by perfusion of 25℃Ringer's solution via the lateral ventricle) and a control group. The contents of water and total sodium, potassium of the brain region close to traumatic brain tissue were detected and pathological changes were observed in three groups. Results The number of the injured neurons was increased significantly in both TBI group and mild hypothermia group than that in control group at 72 h after TBI (P
