Protective effect of Silybin Capsules on hepatic injury induced by combining isoniazid with rifampin in mice
- VernacularTitle:水飞蓟宾胶囊对异烟肼和利福平肝损害小鼠的保护作用
- Author:
Hongyuan XUE
;
Yanning HOU
;
Huichen LIU
;
Jing CHEN
;
Ying CAO
;
- Publication Type:Journal Article
- Keywords:
Silybin Capsules;
isoniazid;
rifampin;
drug interactions;
hepatotoxicity;
hepatoprotection
- From:
Chinese Traditional Patent Medicine
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the protective effect of Silybin Capsules (SC) on mice hepatic toxic injury induced by isonicotinic acid hydrazide (INH) and rifampin (RFP) when used in combination Methods: The serum level of ALT, liver index, contents of glutathion (GSH) and malondialdehyde (MDA), activity of microsomal cytochrome P450 and its isoform P4502E1 in liver were measured. Results: SC obviously inhibited the rising of liver index, serum ALT, liver MDA and the activity of microsomal cytochrom P450 and its isoform P4502E1, and increased the liver GSH. Histopathological examination showed that Silibinin Capsules evidently alleviated the condition of the degeneration of hepatic cells and that of necrosis. Conclusion: The protective effect of SC on mice hepatic injury induced by both IIVit and RFP may be related to stabilizing the liver membrane, inhibiting the the lipid peroxidation, scavenging the free radical and decreasing the activity drug metabolizing enzyme.
