Effect of total flavone in Sanguis Draconis on platelet aggregation,thrombus formation and myocardial ischemia
- VernacularTitle:血竭总黄酮对血小板聚集、血栓形成及心肌缺血的影响
- Author:
Jianjian MA
;
Yan SONG
;
Min JIA
;
Changling LI
;
- Publication Type:Journal Article
- Keywords:
total flavone in Sanguis Draconis (tFSD);
platelet aggregation;
thrombus formation;
myocardial ischemia;
promoting blood circulation and removing blood stasis
- From:
Chinese Traditional and Herbal Drugs
1994;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To investigate the effect of total flavone in Sanguis Draconis (tFSD) on platelet aggregation, thrombus formation and myocardial ischemia in rat and rabbit. Methods Adopting the experimental models including in vitro platelet aggregation in rat and rabbit, in vivo thrombus formation in rat internal vein, and acute myocardial ischemia by ligating the coronary artery. Results In vitro, tFSD could, to a certain degree, inhibit the platelet aggregation induced by ADP and PAF. Moreover, tFSD could markedly restrain artificial thrombus formation in rat internal vein and the area of acute myocardial ischemia after ligating the coronary artery. Conclusion tFSD has the function of promoting blood circulation and removing blood stasis, anti thrombosis, together with platelet aggregation inhibition.
