Effects of ethanol sediments from tuber of Angelica sinensis and its litmusless component on secreting TNF-? and IL-1 of macrophages in vitro
- VernacularTitle:当归醇沉物及其中性组份体外对巨噬细胞分泌TNF-?和IL-1的影响
- Author:
Jinlei XI
;
Renxiu PENG
;
Zhiyong WANG
;
- Publication Type:Journal Article
- Keywords:
ethanol sediments from the tuber of Angelica sinensis (Oliv.) Diels (ESA);
macrophages;
TNF ?;
IL 1
- From:
Chinese Traditional and Herbal Drugs
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Object To investigate the effects of ethanol sediments obtained from the tuber of Angelica sinensis (Oliv). Diels (ESA) and its litmusless component (ESA 1) on the secretion of TNF ? and IL 1 by mice peritoneal macrophages in vitro. Methods L929 cell line cytotoxicity was used for the assay of TNF ?. The proliferation of L929 cell line was used for the assay of IL 1. Results The secretion of TNF ? and IL 1 by mice peritoneal macrophages which were co cultured with ESA or ESA 1 in vitro can be significantly promoted. At the concentrations in range of 5～20 ?g/mL, there is a dose dependence in the action of ESA, while there is not the similar effect of ESA 1, even though it showed the marked effect. Conclusion ESA and ESA 1 can enhance the secreting TNF ? and IL 1 of mice peritoneal macrophages in vitro.
