Potential in for PKC inhibitor Rottlerin in murine experimental model of asthma
- VernacularTitle:用PKC抑制剂Rottlerin治疗小鼠实验性哮喘的研究
- Author:
Jianyong SONG
;
Yuxiang REN
;
Hui LIN
;
Xiaomin ZHANG
;
Jianxun SONG
;
- Publication Type:Journal Article
- Keywords:
asthma;
PKC inhibitor;
allergy;
inflammation;
cytokine
- From:Journal of Third Military Medical University
2003;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the potential role of PKC inhibitor Rottlerin in the treatment of asthma. Methods Balb/c mice were sensitized and challenged with ovalbumin(OVA) protein to construct murine experimental model of asthma. Then the mice were treated by means of injection of Rottlerin or phosphate buffered saline (PBS) into the abdominal cavity. Changes of the total serum IgE, pulmonary eosinophils, cytokines and pulmonary inflammation were investigated. Results Injection of Rottlerin at the dose 0.3 mg/kg into the murine abdominal cavity could inhibit the infiltration of pulmonary eosinophils and pulmonary inflammation and significantly decrease the production of total serum IgE and Th 2 cytokines as well. Conclusion Rottlerin can inhibit murine experimental asthma.
