Anti-oxidative effect of total extract of astragalus(TEA) on aging mice
- VernacularTitle:黄芪总提取物抗衰老作用的实验研究
- Author:
Hong LEI
;
Bin WANG
;
Wei-Ping LI
;
Yan YANG
;
Ai-Wu ZHOU
;
Min-Zhu CHEN
;
- Publication Type:Journal Article
- Keywords:
astragalus;
aging;
D-galactose;
LPO;
GSHpx;
Mn-SOD;
glutathione
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the mechanism of the anti-aging effect of total extract of astragalus(TEA) in mice. Methods MDA content, the activities of Mn-SOD and GSHpx and the reduced to oxidized glutathione (GSH/GSSG) ratio in mitochondria of D-galactose(D-gal) treated mice and 17-month-old mice were measured. Results Treatment with TEA(40 mg?kg-1?d-1 ig) for 10 wk would lower the content of MDA and restore activities of Mn-SOD,GSHpx and GSH/GSSG ratio in mitochondria of D-gal treated mice.Treatment with TEA (40 mg?kg-1 ?d-1 ig) for 3 mon had the same effect on 17-month-old mice.Conclusion TEA has anti-aging effect on D-gal treated mice and 17-month-old mice significantly, probably being related to its anti-oxidative effect.
