ANTIARRHYTHMIC EFFECT OF TOTAL FLAVONES OF HIPPOPHASE RHAMNOIDES IN THE ISOLATED HEART
- VernacularTitle:沙棘总黄酮对离体心脏的抗心律失常作用
- Author:
Fengming LIU
;
Zengxi LI
;
Shan SHI
;
- Publication Type:Journal Article
- Keywords:
Hippophase Rhamnoides L;
Total flavones;
Antiarrhythmic agents;
Isolated rat heart;
Isolated guinea pig atrium;
Ventricular fibrillation threshold
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In the isolated perfused rat heart, TFH counteracted significantly the arrhythmias caused by perfusing with a solution without oxygen; increased ventricular fibrillation threshold markedly and showed a good dose-effective relation; prolonged the P-R period of electrocardiogram and decreased the heart rate and fell the amplitude of cardiac contraction markedly; and counteracted significantly the decrease of the heart rate and the amplitude of cardiac contraction caused by perfusing with a solution without oxygen. In the isolated guinea pig left atrium, TFH prolonged the function refractory period slightly. In the isolated guinea pig right atrium, TFH increased the accumulated dose of aconitine inducing arrhythmias.
