Anti-acute rejection effect of ethanol extract of poria cocos wolf in heart transplantation rats
- VernacularTitle:茯苓醇提取物抗心脏移植急性排斥反应的实验研究
- Author:
Guowei ZHANG
;
Qiuming XIA
;
- Publication Type:Journal Article
- Keywords:
Poria cocos;
Heart transplantation;
Graft rejection;
Immunosuppression
- From:
Chinese Journal of Organ Transplantation
1996;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti acute rejection effect of ethanol extract of poria cocos wolf (EEPCW) in heart transplantation rats.Methods Homologous heart transplanted rats were divided into 4 groups ( n =20 in each group). EEPCW 50?mg?kg -1 ?d -1 , EEPCW 25?mg?kg -1 ?d -1 , CsA 5?mg?kg -1 ?d -1 and olive oil 8?ml?kg -1 ?d -1 were given to different groups. Cardiac allograft survival was observed on 10 of each groups. The pathologic lesion, the contents of IL 2 and IFN ? in peripheral blood, percentage of CD3 +, CD4 +, CD8 + lymphocytes and ratio of CD4 +/CD8 + were determined on another 10 in each groups and 10 normal rats. Results Survival of the donor heart was significantly prolonged and pathologic lesion was relieved, the contents of IL 2 and IFN ? in peripheral blood, percentage of CD3 +, CD4 +, CD8 + lymphocytes and ratio of CD4 +/CD8 + were significantly reduced in EEPCW groups.Conclusion Acute rejection of heart transplantation can be effectively suppressed by ethanol extract of poria cocos wolf.
