Protective effect of Salvia Miltiorrhizae on the renal injury of rats with obstructive jaundice
- VernacularTitle:丹参对梗阻性黄疸肾损害保护作用的实验研究
- Author:
Jinchi ZHANG
;
Yongkun LIN
;
Pingfan GUO
;
- Publication Type:Journal Article
- Keywords:
Silvia Miltiorrhizae;
Cholestasis;
Kidney;
Malondialdehyde;
Superoxide dismutase;
Pathology,surgical
- From:Chinese Journal of Current Advances in General Surgery
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the mechanism of Salvia Miltiorrhizae(SM) on protecting the renal injury of rats with obstructive jaundice.Methods:The 36 rats were randomly divided into control group,obstructive jaundice group and SM treated group.The renal injury of rats model with obstructive jaundice was established by ligating common bile duct.In the SM treated group,SM (2.0g/ d) was given through abdominal cavity.Animals were killed at the 7th,14th,21st and 28th day after operation respectively.The malondialdehyde (MDA) and superoxide dismutase (SOD) activity content of serum and renal tissue were determined,and the changes of renal function and histopathology were observed.Results:Comparing with non treated group,the serum and renal tissue SOD activity were markedly increased,and the MDA were obviously decreased(P
