The protective effect of lactulose on the impaired renal function by endotoxemia in acute cholelithiasis with obstructive jaundice
- VernacularTitle:乳果糖对急性胆道梗阻并内毒素血症患者肾功能的保护作用
- Author:
Kai ZHENG
;
Chengyou WANG
;
Ming XU
;
Mingjie ZHANG
;
Wengjian HUANG
;
- Publication Type:Journal Article
- Keywords:
CHOLELITHIASIS/compl;
TOXEMIA/etiol;
KIDNEY FAILURE/prev;
LACTULDSE/ther use
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect and mechanism of lactulose on the renal function in acute cholelithiasis with obstructive jaundice. Methods Fifty five cases of acute cholelithotic obstruction were randomly assigned into lactulose group (group L, n=28) and control group (group C, n=27), and 50% lactulose (group L)or 10% glucose (group C ) was administered orally for 3 days before the operation , respectively. The systemic and portal blood endotoxin (ET), blood urea nitrogen (BUN) and endogenous creatinine clearance rate (Ccr) were measured periodically. Results (1) In group L, the level of systemic vein ET and BUN were significantly lower than that in group C (P0.05); and the systemic vein ET and Ccr decreased significantly on 9d (P
