Inhibitory effects of total flavones of Metasequoia glyptostroboides on experimental cardiac hypertrophy and expression of c-Fos protein in ventricle
- VernacularTitle:水杉总黄酮抗实验性心肌肥厚及抑制心室 c-Fos 蛋白表达的作用
- Author:
Wei-wan LIU
;
WEI-WAN LIU
;
Xiao-ru YANG
;
Ming-jian SHI
;
Hong-ying WANG
;
Ying AO
;
Zhi-ben TU
;
- Publication Type:Journal Article
- Keywords:
total flavones of Metasequoia glyptostroboides Hu et Cheng (TFM);
volume-overload;
cardiac hypertrophy;
c-Fos
- From:
Chinese Traditional and Herbal Drugs
2001;32(4):329-332
- CountryChina
- Language:Chinese
-
Abstract:
To observe the effects of total flavones of Metasequoia glyptostroboides Hu et Cheng (TFM) on volume-overload cardiac hypertrophy and the expression of c-Fos protein in rat. Methods Volume-overload cardiac hypertrophy of rat was induced by aortocaval shunts. The rats were given ig TFM (400, 40 and 4 mg/kg/d). c-Fos protein in the ventricles were measured by immunocytochemical study. Results TFM at the above dosage decreased heart weight and contents of RNA and protein in the myocardium, inhibited the expression of c-Fos protein in the ventricles. Conclusion TFM can prevent volume-overload cardiac hypertrophy in rats. The inhibitory effects on the expression of c-Fos protein may be its mechanism in the molecular level.
