The Hypothesis of Elucidating the Cardioprotective Absorbed Bioactive Compounds of Danggui-Buxue-Tang with the Method of Bioethnopharmaceutical Analytical Pharmacology
10.11842/wst.2016.07.006
- VernacularTitle:生物方剂分析药理策略阐明当归补血汤心脏保护药效学物质基础的设想
- Author:
Kuipo YAN
;
Cuiling ZHU
;
Yanqin SUN
;
Mingjun ZHU
;
Xincan LIU
- Keywords:
Bioethnopharmaceutical analytical pharmacology;
Dangui-Buxue Tang;
absorbed bioactive compounds;
hypothesis
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2016;18(7):1121-1125
- CountryChina
- Language:Chinese
-
Abstract:
Bioethnopharmaceutical analytical pharmacology (BAP) means to study Chinese herbal compound formula (CHCF) from the aspacts of in vivo and in vitro efficacy,pharmacodynamics,quality control and plant chemistry,guided by the CHCF absorbed bioactive compounds (ABC) analyses.The form of BAP is performed by comparing ABC efficacy with mother formula efficacy.Meanwhile,it must follow the principle which the ABC dose should be equal to the mother formula content or the blood drug concentration.In this study,the hypothesis was put forward to clarify the thoughts,assumptions and expected results,which uncovered the multiple cardioprotective mechanism of Dangui-Buxue Tang (DBT) for ischemic heart disease.BAP is expected to guide the development of further experiments for providing a better thought for the research over CHCF.
