Expression of Receptor for Advanced Glycation End Products in a Rat Model of Polycystic Ovarian Syndrome

VernacularTitle:晚期糖基化终产物受体在多囊卵巢综合征大鼠模型中的表达
Author: Yannan ZHAO ¹ ; Hongxiang LIU ; Xiaoxin MA
Author Information

1. 中国医科大学附属盛京医院妇产科
Keywords: polycystic ovarian syndrome; receptor for advanced glycation end products; rat model
From: Journal of China Medical University 2017;46(9):769-772
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of receptor for advanced glycation end products (RAGE) and soluble RAGE (sRAGE) in a rat model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS) and to explore the role of sRAGE in ovarian function.Methods The PCOS rat model was established using dehydroepiandrosterone in combination with a high-fat diet.In animals with confirmed PCOS induction,serum concentrations of sRAGE and AMH were measured by competitive ELISA,and RAGE expression in ovarian tissues was detected by immunohistochemistry.Results RAGE expression was significantly higher in the PCOS group than in the control group (P ＜ 0.01).Serum concentrations of sRAGE and AMH were significantly lower and higher than those in the control group (P ＜ 0.05),respectively.Furthermore,sRAGE level was negatively correlated to that of AMH.Conclusion RAGE and sRAGE levels influence ovarian function and have substantial reference value in the diagnosis and pathogenesis of PCOS.