Role of long non-coding RNA in drug resistance of tumor

VernacularTitle:长链非编码RNA在肿瘤耐药中的作用
Author: ru Meng GAO ¹ ; li Xiao WEI ; sheng Kang GU
Author Information

1. 安徽医科大学第一附属医院肿瘤内科
Keywords: long non-coding RNA; tumor; drug resistance; mo-lecular mechanism; gene regulation; target
From: Chinese Pharmacological Bulletin 2017;33(12):1641-1645
CountryChina
Language:Chinese
Abstract: Long non-coding RNA(lncRNA)is a class of RNAs with a number of nucleotides greater than 200,no specific open reading frame and no protein coding. LncRNA could have a sig-nificant influence on the regulation of gene expression during cell growth,and also play a potential role in the development,pro-gression and resistance of tumors. Consequently,it becomes a new tumor research hot spot after miRNA. Many studies have shown that aberrant expression of lncRNA may lead to anti-tumor drug resistance. Furthermore,this resistance is not only derived from individual differences in patients,but also from genetic and epigenetic differences in the tumor. In this paper,we summarize the recent advances in lncRNAs associated with drug resistance that may help overcome drug resistance,so as to improve and develop new therapeutic strategies.