FGF23-Klotho and its correlation with abnormal bone metabolism

VernacularTitle:FGF23-Klotho与骨代谢异常的相关性
Author: Yue LIU ¹ ; Yanmei ZHANG ; Hu ZHAO
Author Information

1. 复旦大学附属华东医院检验科
Keywords: Bone diseases; metabolic; FGF23-Klotho axis; Skeletal metabolic disorders; Target of diagnosis and treatment
From: Chinese Journal of Laboratory Medicine 2017;40(11):839-843
CountryChina
Language:Chinese
Abstract: Skeletal metabolic disorder refers to multi-factors caused by bone tissue calcium, phosphorus and other minerals,osteoblasts and(or)osteoclast dysfunction.The FGF23-Klotho axis plays an important role in the bone-kidney-parathyroid axis and is involved in the regulation of bone mineral metabolism.At the same time, FGF23-Klotho axis affects the synthesis and secretion of vitamin D and parathyroid hormone.With the deepening of research,the FGF23-Klotho axis is promising to be the target of diagnosis and treatment of bone metabolic disorders.