FGF23-Klotho and its correlation with abnormal bone metabolism
10.3760/cma.j.issn.1009-9158.2017.11.002
- VernacularTitle:FGF23-Klotho与骨代谢异常的相关性
- Author:
Yue LIU
1
;
Yanmei ZHANG
;
Hu ZHAO
Author Information
1. 复旦大学附属华东医院检验科
- Keywords:
Bone diseases;
metabolic;
FGF23-Klotho axis;
Skeletal metabolic disorders;
Target of diagnosis and treatment
- From:Chinese Journal of Laboratory Medicine
2017;40(11):839-843
- CountryChina
- Language:Chinese
-
Abstract:
Skeletal metabolic disorder refers to multi-factors caused by bone tissue calcium, phosphorus and other minerals,osteoblasts and(or)osteoclast dysfunction.The FGF23-Klotho axis plays an important role in the bone-kidney-parathyroid axis and is involved in the regulation of bone mineral metabolism.At the same time, FGF23-Klotho axis affects the synthesis and secretion of vitamin D and parathyroid hormone.With the deepening of research,the FGF23-Klotho axis is promising to be the target of diagnosis and treatment of bone metabolic disorders.
