Effects of rapamycin on blood lipid metabolism in renal transplant recipients
10.3760/cma.j.issn.1673-4203.2017.09.017
- VernacularTitle:雷帕霉素对肾移植受者血脂代谢的影响
- Author:
Yingxin FU
1
Author Information
1. 天津市第一中心医院移植外科天津市器官移植临床医学研究中心
- Keywords:
Kidney transplantation;
Lipid metabolism disorders;
Cytokines;
Autophagy;
Rapamycin
- From:
International Journal of Surgery
2017;44(9):633-636
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,rapamycin has been used as an immunosuppressive agent in clinical practice.Rapamycin has the effect of accelerating lipid metabolism in the test,but it has the adverse reaction of hyperlipidemia at the same time.In view of this double-side conclusion,this article mainly analyzes the following aspects:direct inhibition of mTOR pathway,reduce expression of peroxisome proliferator-activated receptor γ,inhibition of leptin secretion,down-regulation of cholesterol-regulating element binding protein and excitation cell autophagy.Based on current research at home and abroad,it suggested that the the effects of dose-response effects of rapamycin and the exact mechanism of interaction between PI3K/PKB/mTOR signaling pathways and other cytokines can be a further research direction,so that the relationship between rapamycin and blood lipid metabolism can be learn more about in a quantify way.
