GATA3-IL-13 pathway gene polymorphisms are associated with serum IL-13 and asthma
10.3969/j.issn.1000-484X.2017.12.019
- VernacularTitle:GATA3-IL-13通路基因多态性和IL-13水平与哮喘病的相关性研究
- Author:
Yang Guang ZHANG
1
;
Jie Yao GUO
;
Yan Yan SUN
;
Man Shan LI
;
Jiang Jian LU
;
Wen Xiao YIN
Author Information
1. 石河子大学化学化工学院/新疆兵团化工绿色工程重点实验室
- Keywords:
IL-13;
GATA3;
Gene polymorphisms;
IL-13 levels;
Asthma
- From:
Chinese Journal of Immunology
2017;33(12):1849-1853
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Asthma is a chronic inflammatory respiratory disease .The data show that involvement of the GATA 3-IL-13 gene in asthma is biologically plausible .The objective of this study is investigated the association of GATA 3-IL13 gene polymorphisms and IL-13 levels with asthma;assess the correlations between GATA 3-IL-13 gene SNPs polymorphisms and serum levels of IL-13 in population of Xinjiang (China).Methods:A case group of 279 patients and 277 healthy controls were genotyped to perform using the MassARRAY SNP genotyping system.In 279 asthma patients and 277 controls,IL-13 levels were measured by ELISA.Data were analyzed using the statistical package for social science (SPSS) 22.0 (IBM,NY,USA) and Graph Pad Prism 6.0.Results:Patients were found that IL-13 levels were associated with asthma in asthmatic and the IL-13 ( rs2066960 AA ) , GATA3 ( rs3781093 CC) genotype was associated with a notably increased risk of asthma compared with the CC (rs2066960),TT (rs3781093) genotype (P<0.05).Similarly,IL-13(rs2066960) C-A alleles were significantly associated with risk of asthma (P<0.05).However,the rs3781093 C-T alleles had no obvious differences (P>0.05).In addition,the patients carrying the rs2066960 AA genotype presented with higher IL-13 levels compared to the CC group .Conclusion:This result suggests that the rs 2066960 C-A variant is associated with IL-33 levels in patients with asthma .
