Meta-analysis on Reinhartdt and Sea Capsule combined with Donepezil in treatment of Alzheimer's disease
10.7501/j.issn.1674-6376.2017.07.023
- VernacularTitle:复方海蛇胶囊联合多奈哌齐治疗阿尔茨海默病的Meta分析
- Author:
Biao DU
1
;
dong Xiao FAN
;
yan Chun ZHANG
;
qiang Wen KONG
;
Yang DU
;
yang Chun ZHOU
Author Information
1. 重庆三峡中心医院药学部
- Keywords:
Reinhartdt and Sea Capsule;
donepezil;
Alzheimer's disease;
Meta-analysis
- From:Drug Evaluation Research
2017;40(7):987-992
- CountryChina
- Language:Chinese
-
Abstract:
Objective Objective To evaluate the efficacy and safety of Reinhartdt and Sea Capsule (RSC) combined with donepezil (experimental group) compared with donepezil (control group) in treatment of Alzheimer's disease.Methods The randomized controlled trials (RCT) of reinhartdt and sea capsule combine with donepezil in treatment of Alzheimer's disease were searched from Pubmed,VIP,CNKI,CBM,and Wangfang detabase by computer.Deadline from January 2000 to February 2017.References of included studies were also retrieved,extracted data,and assessed the methodological quality.Then,Meta-analysis was performed using RevMan 5.0 software.Results A total of eight RCTs were included,including 605 patients with insomnia.Meta-analysis results showed that compared with control group,experimental group MMSE score [P＜0.001,MD=2.69,95％CI(1.46,3.92)],ADAS-Cog score [P＜0.001,MD=-4.54,95％CI(-5.64,-3.43)] and ADL score [P＜0.001,MD=-3.60,95％CI(-4.53,-2.66)],the difference was statistical;There was no signficant difference between two group in the incidences of adverse effect [P=-0.94,OR=1.02,95％CI(0.63,1.66)].Conclusion RSC combined with donepezil showed better efficacy for Alzheimer's disease,yet without increasing adverse effect rate as compared with donepezil alone.
