Clinical comparative study on azithromycin and ceftazidime in treatment of children with refractory mycoplasma pneumoniae pneumonia
10.7501/j.issn.1674-6376.2017.07.019
- VernacularTitle:阿奇霉素和头孢他啶治疗难治性肺炎支原体肺炎患儿的临床对照研究
- Author:
fei Jie WANG
1
Author Information
1. 郑州市妇幼保健院儿科
- Keywords:
azithromycin;
cephalosporin;
refractory mycoplasma pneumoniae pneumonia;
lactate dehydrogenase
- From:Drug Evaluation Research
2017;40(7):971-974
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of azithromycin and cefiazidime on serum lactate dehydrogenase (LDH) in children with refractory mycoplasma pneumoniae pneumonia.Methods From January 2014 to January 2017,120 children with refractory mycoplasma pneumoniae pneumonia in Women and Infants Hospital of Zhengzhou were selected as research object,all the cases were equally divided into observation group and control group with 60 cases in each group according to the random draw envelope principle,the observation group was given azithromycin adjuvant treatment,the control group was given cephalosporin adjuvant therapy,two groups were treated for 14 d.Results The total effective rates of observation group and control group were 98.3％ and 86.7％,respectively,the total effective rate of observation group was significantly higher than that of control group,the difference was statistically significant (P ＜ 0.05).The serum levels of LDH in observation group and control.group after treatment were (143.22±26.29) and (245.10 ± 30.91) U/L that were significantly lower than those before treatment of (445.20 ± 35.10) and (438.10 ± 56.11) U/L (P ＜ 0.05),and the serum level of LDH in observation group after treatment was significantly lower than that of the control group (P ＜ 0.05).The incidence of adverse reactions such as rash,gastrointestinal reaction,pain,fever and other adverse reactions in the observation group was 11.7％,which was 10.0％ in the control group.Comparison between the two groups had not significant difference (P ＜ 0.05).Conclusion Compared with cephalosporins,azithromycin in the treatment of refractory mycoplasma pneumoniae pneumonia in children can improve the therapeutic effect,and does not increase the incidence of adverse reactions,the mechanism may be related to the decrease of the content of serum LDH.
