Protective effects of Cerebroprotein Hydrolysate for injection (I) on vascular dementia in rats
10.7501/j.issn.1674-6376.2017.07.007
- VernacularTitle:注射用脑蛋白水解物(I)对血管性痴呆大鼠的保护作用
- Author:
long Xiao JING
1
;
bao Yan HOU
;
ming Lei REN
;
Li MA
;
Yan HUANG
;
Jing LIU
;
ping Xiu SHEN
Author Information
1. 天津药物研究院新药评价有限公司
- Keywords:
Cerebroprotein Hydrolysate for injection (I);
vascular dementia;
IGF-1;
learning and memory
- From:Drug Evaluation Research
2017;40(7):922-925
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of Cerebroprotein Hydrolysate for injection (I) on vascular dementia (VaD) in rats.Method The permanent bilateral common carotid artery ligation method was used to prepare a VaD rat model.Suture of rats was performed after separation of the common carotid artery in Sham group.The model rats were randomly divided into model group,Cerebroprotein Hydrolysate Injection (Cerebrolysin,10 mg/kg,positive drug group),Cerebroprotein Hydrolysate for injection (I) high,medium and low dose (20,10 and 5 mg/kg) groups.Rats were treated with relative drug by tail iv injection once daily for two weeks,and rats in Sham group were given equal volume of saline.The learning and memory abilities were evaluated by Y maze and step-through tests.Besides,the levels of insulin-like growth factor-I (IGF-1) in VaD rat serum were determined by ELISA method.Results Compared with model group,Cerebroprotein Hydrolysate for injection (I) significantly increased the correct number in Y maze test,reduced the step-through latency time,and elevated serum IGF-1 level in VaD rats.The protective effects of Cerebroprotein Hydrolysate for injection (I) in VaD rats were equivalent to the same dose of Cerebrolysin.Conclusion Cerebroprotein Hydrolysate for injection (I) could significantly improve the learning and memory abilities of VaD rats,presumably through a mechanism of elevating IGF-1 level,which promotes the repairment and growth of neurons.
