Clinical effect of Spleen Aminopeptide Oral Lyophilized Powder combined with azithromycin on mycoplasma pneumonia in children and its influence on immune function
10.7501/j.issn.1674-6376.2017.07.014
- VernacularTitle:脾氨肽口服冻干粉联合阿奇霉素治疗小儿支原体肺炎的疗效及对免疫功能的影响
- Author:
xiang Xiao LI
1
;
Li ZHOU
;
Liang ZHAO
;
sheng Bian ZHOU
Author Information
1. 开封市儿童医院感染与传染科
- Keywords:
mycoplasma pneumonia;
children;
Spleen Aminopeptide Oral Lyophilized Powder;
azithromycin;
immune
- From:Drug Evaluation Research
2017;40(7):950-954
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of Spleen Aminopeptide Oral Lyophilized Powder on mycoplasma pneumonia in children and its influence in immune function.Methods Totally 103 cases of children infected with mycoplasma pneumonia from May 2013 to June 2016 were selected and divided into observation group and control group,with 53 cases in each group.The control group were treated with azithromycin,and observation group were treated with azithromycin combined with Spleen Aminopeptide Oral Lyophilized Powder.The clinical effect,T cell subgroup (CD4+,CD8+,CD4+/CD8+) levels,serum cytokine levels (IL-10,IL-17,TGF-β1) and safty were compared.Results The total effective rate of the observation group was 94.39％,which was significantly higher than that of the control group of 79.25％ (P ＜ 0.05).After treatment,the levels of CD4+,CD4+/CD8+ in two groups were significantly higher than those before treatment (P ＜ 0.05),and the levels of CD4+,CD4+/CD8+ in observation were higher than those in control group significantly (P ＜ 0.05).The levels of CD8+,IL-10,IL-17,TGF-β1 in two groups were significantly lower than before treatment (P ＜ 0.05),and those indexes in observation were lower than those in control group,the difference was statistically significant (P ＜ 0.05).Conclusion Azithromycin combined with Spleen Aminopeptide Oral Lyophilized Powder has remarkable clinical effect on mycoplasma pneumonia in children,which is cecurity and reliable,and can improve the cellular immune function and reduce the immune injury.
