Effect of lidocaine on the postoperative inflammatory factors and cognitive dysfunction for elderly patients undergoing spinal operation
10.7501/j.issn.1674-6376.2017.07.021
- VernacularTitle:利多卡因对老年脊柱手术患者术后炎症免疫反应及认知功能的影响
- Author:
yun Hong WANG
1
;
hui Zhen GAO
;
Bin LIANG
;
ping Jun NING
Author Information
1. 宝鸡市中心医院麻醉科
- Keywords:
aged patients undergoing spinal operation;
lidocaine;
immunity;
inflammatory factors;
postoperative cognitive dysfunction
- From:Drug Evaluation Research
2017;40(7):979-982
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of lidocaine with intravenous infusion on the postoperative inflammatory factors and cognitive dysfumction for elderly patients undergoing spinal operation.Method 80 elderly patients undergoing spinal operation in Central hospital of Baoji were enrolled from Janua-y 2015 to January 2016,of which patients divided into two groups randomly,control group (n =40) accepted routine general anesthesia,and study group (n =40) adopted intravenous lidocaine based on the patiems in control group,comparing the MMSE score and the incidence of postoperative cognitive dysfunction (POCD) with before operation,detecting and analyzing the difference of inflammatory and immunity factors.Results The MMSE score of the study group after three days of operation was significantly lower than that of the control group,the difference was statistically significant (P ＜ 0.05).The incidence of POCD in the study group was significantly lower than that in the control group,the difference was statistically significant (P ＜ 0.05).The serum levels of IgA,IgM and IgG in the study group after seven days of operation were significantly higher than those in the control group,the difference was statistically significant (P ＜ 0.05).After three days and seven days postoperatively,the serum levels of interleukin-6 (IL-6) in the study group were significantly lower than those in the control group,the difference was statistically significant (P ＜ 0.05).And there was no significance of TNF-α between two groups at any time point.Conclusions Intravenous lidocaine for patients undergoing spinal operation could inhibit the inflammatory response,improve the function of immunity,and decrease the incidence of POCD,which deserved popularization in clinic.
