Correction of matrix effect in determination of heavy metal elements in iron dextran by icp-oes internal standard method
10.7501/j.issn.1674-6376.2017.08.012
- VernacularTitle:电感耦合等离子体发射光谱法测定右旋糖酐铁中重金属元素时的基体效应和内标校正方法研究
- Author:
Chao MA
1
;
Ce MENG
;
xia Cai ZHANG
;
yi Xin CHENG
;
Bo WANG
;
wen Xia REN
Author Information
1. 天津药物研究院药物制剂研究中心
- Keywords:
inductively coupled plasma optical emission spectrometry (ICP-OES);
matrix effect;
internal standard method;
iron dextran
- From:Drug Evaluation Research
2017;40(8):1098-1102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a method for the determination of 8 heavy metal elements of Pb,Cd,As,Hg,Co,V,Se,Mo in iron dextran by inductively coupled plasma optical emission spectrometry (ICP-OES).Method Through selection of detection wavelengths,optimization of instrument parameters,verification of matrix effect interference and investigation of internal standard for correction of matrix effect interference,the 8 heavy metal elements were analyzed by ICP-OES.Results The recovery rate of the detected elements were increased from 83％-90％ to 94％-100％,after correction of matrix effect interference by internal standard method.The accuracy of the method were good.The spiked recoveries of the detected elements were from 94.3％ to 101.5％.The precision of the method were good (RSD ＜ 3.5％,n =6).The linearities of the detected elements were good,and the correlation coefficients were all greater than 0.999.The detection limits were from 0.22 to 8.54 ng/mL.The quantization limits were from 0.68 to 25.73 ng/mL.Conclusion The established method was accurate,sensitivity,rapid and reliable,which can be applied to the determination of contents of 8 heavy metal elements in iron dextran.
