Synthesis and Anti-wrinkle Efficacy of Botox-like Polypeptide
10.3870/j.issn.1004-0781.2017.10.006
- VernacularTitle:类肉毒多肽的合成与祛皱效果
- Author:
Wenfeng DING
1
;
Qingqin LYU
;
Jiyong ZHANG
;
Yanmin LAI
;
Yanrong CHEN
Author Information
1. 深圳市维琪医药研发有限公司
- Keywords:
Active polypeptide;
Botox-like;
Anti-wrinkle;
Anti-aging;
Muscle contraction
- From:
Herald of Medicine
2017;36(10):1112-1115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a new botox-like polypeptide with anti-wrinkle and anti-aging functions, which will be used in the field of cosmetics and dermatology. Methods A series of new peptide compounds were synthesized via modifying the structure of SYN-AKE by peptide synthesis technology. Simulating muscle contraction by using co-culture model of human muscle cells and mouse embryonic spinal cord neurons to test the effects. Results Six new synthetic peptides were selected. The results showed that the muscle contraction frequency was lowered by adding C19 H30 N5 O4 compound than adding SYN-AKE in 1 min(P<0.05). Conclusion C19H30N5O4 is expected to become a new cosmetic peptide raw material and dermatology drug in the field of anti-wrinkle and anti-aging.
