Association of single nucleotide polymorphism of SIRT1 gene with age-related cataract
10.13389/j.cnki.rao.2017.0238
- VernacularTitle:年龄相关性白内障患者沉默信息调节因子1(SIRT1)的单核苷酸多态性研究
- Author:
Hua Li KANG
1
;
Xi ZOU
;
Mei YANG
;
Jin Huai GUAN
Author Information
1. 南通大学附属医院眼科
- Keywords:
silent information regulator 1;
single nucleotide polymorphism;
age related cataract
- From:
Recent Advances in Ophthalmology
2017;37(10):939-942
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of single nucleotide poly morphisms (SNP) of silent information regulator 1 (SIRT1) gene with age-related cataract (ARC) in Jiangsu Har population.Methods Population-based case-control study was conducted in 720 cataract cases and 701 healthy controls,who were selected from the database of Funing County of Northern Jiangsu and Binhu District of Wuxi city of Southern Jiangsu.Five SNPs of SIRT1 gene (rs2236319,rs1885472,rs10997868,rs2273773 and rs4746720) were genotyped by Taq-Man RT-PCR methods.Results The genotype of 2 SNPs in SIRT1 (rs2236319 and rs1885472) was AA/AG/GG and CC/CG/GG respectively,and the genotype frequency in the controls was 40.08％,52.60％,7.32％ and 35.81％,35.23％,28.96％ respectively,while the frequency in ARCs was 36.94％,56.25％,6.81％ and 36.67％,32.92％,30.42％,respectively.The genotype of another 2 SNPs in SIRT1 (rs2273773 and rs4746720) was both CC/CT/TT,and the genotype frequency in the controls was 38.37％,54.78％,5.85％ and 74.75％,17.69％,7.56％ respectively,while the frequency in ARCs was 39.58％,54.17％,6.25％ and 71.81％,20.97％,7.22％,respectively.And there was no significant difference between the two groups (P ＞ 0.05).Conclusion All the five SNPs of SIRT1 gene are not associated with ARC in the Jiangsu Han population.
