Expression and Clinical Meaning of Plasma Soluble Receptor of Advanced Glycation End Product in Patients With Gestational Hypertension Heart Disease
10.3969/j.issn.1000-3614.2017.09.019
- VernacularTitle:血浆可溶性晚期糖基化终末产物受体在妊娠期高血压性心脏病的表达及其临床意义
- Author:
Kun ZUO
1
;
De CHEN
;
Mei WANG
;
ning Jun JING
;
Song DU
;
Qing LIU
Author Information
1. 甘肃省妇幼保健院急诊科
- Keywords:
Hypertension,pregnancy-induced;
Glycosylation end products,advanced;
Natriuretic peptide,Brain
- From:Chinese Circulation Journal
2017;32(9):913-916
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression and clinical meaning of plasma soluble receptor of advanced glycation end product (sRAGE) in patients with gestational hypertension heart disease.Methods:Our research included in 2 groups:Observation group,n=57 patients with gestational hypertension heart disease who were diagnosed and treated in our hospital from 2013-06 to 2016-07;Control group,n=57 healthy pregnant women at the same period of time.Based on cardiac function,the patients in Observation group was divided into 4 subgroups as NYHA Ⅰ,Ⅱ,Ⅲ and ⅣV;according to 28-day surviving,the patients were divided into another set of 2 subgroups as Survival subgroup,n=49 and Death subgroup,n=8.Plasma levels of sRAGE and BNP were examined within 24h of admission.The changes of sRAGE were compared among different groups and the impact of sRAGE on gestational hypertension heart disease prognosis was analyzed.Results:Compared with Control group,Observation group had increased plasma sRAGE (939.2±184.3) pg/mL vs (467.3±116.2) pg/mL,P＜0.05;sRAGE level was positively related to NYHA grading (r=0.76,P＜0.001),sRAGE had an elevating trend upon NYHA grade increasing accordingly,P＜0.05.Compared with Survival subgroup,Death subgroup had increased plasma sRAGE (1647.6±249.7) pg/mL vs (776.9±146.2) pg/mL,P＜0.05.The areas of sRAGE and BNP under ROC curve were 0.91 and 0.88 respectively,P＜0.05.Conclusion:Plasma sRAGE was increased in patients with gestational hypertension heart disease;it was related to severity of heart failure (HF) and could be used for predicting the early prognosis in HF patients.
