Expression of ASPP2 and P16INK4a and its relationship with apoptosis in esophageal carcinoma
10.3969/j.issn.1006-5725.2017.19.024
- VernacularTitle:ASPP2及P16INK4a在食管癌中的表达及其与凋亡的关系
- Author:
Fengyu LI
1
;
Limei WANG
;
Shuxia WEI
;
Yang LYV
;
Xiujuan LI
;
Rou LI
Author Information
1. 中国人民解放军第251医院肿瘤内科
- Keywords:
esophageal carcinoma;
ASPP2;
P16INK4a;
immunohistochemistry;
TUNEL;
apoptosis
- From:
The Journal of Practical Medicine
2017;33(19):3247-3250
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of ASPP2 and P16INK4a in esophageal carcinoma and their relationship to the apoptosis and related clinicopathological characteristics. Methods Immunohistochemistry S-P method was used to examine the expression of ASPP2 and P16INK4a in the pathological specimens of 112 esophageal carcinoma cases and 31 cases of normal esophageal mucosa. TUNEL was also employed to detect the rate of apopto-sis in 37 esophageal carcinoma cases and 12 cases of normal esophageal mucosa. Results The difference between the expression of ASPP2 and P16INK4a in esophageal carcinoma and normal esophageal mucosa was statistically signif-icant(P < 0.05). Their abnormal expressions were all related to lymph node metastasis and differentiation degree (P < 0.05). The difference between the positive rate of apoptosis in esophageal carcinoma and normal esophageal mucosa was statistically significant(P < 0.05). The abnormal expression of ASPP2 and P16INK4a was all related to apoptosis in esophageal carcinoma. Conclusions The different expression of ASPP2 and P16INK4a may cooperatively play a role in differentiation degree ,lymph nodes metastasis and apoptosis in esophageal carcinoma. Co-examina-tion of them may be useful for the diagnosis and guiding the clinical treatment in esophageal carcinoma.
